• M.Sc. (Bio-Science) 1997,
• Ph.D (Chemistry - Medicinal chemistry and Pharmacology) 2007

Phytochemistry

• Started his research work in 2003 at Mysore University, Karnataka, India and completed Ph.D in 2007 in the area of Medicinal Chemistry and Pharmacology (Synthesis and Pharmacological action of piperazine derivatives and non-ester analogues of arecoline related to Alzheimer’s disease). He has a good expertise in Synthesis Organic chemicals, characterization using spectral methods conducting invivo animal based experiments, in vitro isolated tissue based experiments, care breeding, and management of laboratory animals in performing biochemical assay and cell based assay and spectrophotometric techniques. The goal of his research efforts is the development of biological treatments for the disease; neurological disorders Acetyl cholinesterase inhibition assay, anti-inflammatory activity, and antimicrobial activity.
• He has started has carrier in1998 has a Senior Chemist in Charka Pharmaceuticals Company Karnataka, India and engaged in the manufacturing of ayurvedic liquid and tablet formulation and quality control of semi finished and finished ayurvedic products.
• He has worked in (2002-2004) M/s TAB Ayurveda Mandya Karnataka, and handles the project of cultivation and distillation of aromatic oils.
• Now at present he is working as Scientist in phytochemistry department engaged in standardization of medicinal plants, extraction, isolation, characterization and quantification of biomarkers using different analytical technique and validation of medicinal plants through invivo and invitro pharmacological models. During this research period he has 23 papers in national and international journals to his credit.

• Participated in the 19th Indian Council of Chemist (ICC Conference), Mysore, December 21-24, 2001
• Participated and poster presentation in National Symposium on Bio Organic Medicinal Chemistry, University of Mysore, Mysore, October 7-9, 2005.
• Participated in the Joint International Conference on Advances in Organic Chemistry and Chemical Biology (AOCCB2006) January 11-12, 2006
• Participated in the 19th Indian Council of Chemists (ICC Conference), December 27-29, 2006.
• Participated in the Indo-Canadian Symposium Medicinal Plants and Functional Foods in the Management of Diabetes, obesity and Cardiovascular Disease March 2008 Aurangabad
• Participated in the National Conference on Recent Trends In Plant Science February 2008 Bangalore
• Participated in the 1st International Euro-India Conference Holistic Medicine (ICHM) August 21-23, 2008. Kottayam, Kerala 

Total Publications

23 research papers

2

Selected Publications

1

C.T. Sadashiva, P. Sharanappa, S. Ravi, A. Thimmegowda and Indira Balachandran. 2008. (In press)  “Quantitative Determination of and Phytochemical Investigation of Essential oil of Orthosiphon diffusus” Journal of Essential oil Research.

2

J. N. Narendra Sharath Chandra, K. C. Ponnappa, C. T. Sadashiva, B. S. Priya, B. L. Nanda, T. Veerabasappa Gowda, B. S. Vishwanath, and K. S. Rangappa, “Chemistry and Structural Evaluation of Different Phospholipase A2 Inhibitors in Arachidonic Acid Pathway Mediated Inflammation and Snake Venom Toxicity”, Current topics in medicinal Chemistry. 7, 2007, 787-800.

3

J. N. Narendra Sharath Chandra, C. T. Sadashiva, C. V. Kavitha and K. S. Rangappa. “Different Susceptible Genes in Alzheimer’s Disease”, my SCIENCE.2(1) 2007, 1-12.

4

S. B Benaka Prasad., Y. C Sunil Kumar., C. S Ananda Kumar., C. T. Sadashiva, K Vinaya and K. S. Rangappa. “Synthesis of Novel N- Methyl-1,2,5,6-tetrahydropyridine-3- Derivatives by Suzuki Coupling: As Acetylcholinesterase Inhibitors”, The open medicinal chemistry journal. 1, 2007, 4-10.

5

C. V. Kavitha, S. L.Gaonkar, J. N. Narenrda Sharath Chandra, C. T. Sadashiva, K. S. Rangappa. “Synthesis and Screening for Acetylcholinesterase Inhibitor Activity of Some Novel 2-butyl-1,3-diaza-spiro [4,4]non-1-en-4-one Derivatives of Irbesartan key Intermediate’’, Medicinal Chemistry.15, 2007, 7391-7398.

6

J. N. Narendra Sharath Chandra, Girisha, C. T. Sadashiva, Sriramamurthy Bopanna, Manish Malvia and Kanchugarakoppal S. Rangappa. “Active Site Directed Docking Studies, Synthesis and Pharmacological Evaluation of Cis- 2,6-dimethyl Piperidine Sulfonamides as Reversible Inhibitors of Acetylcholinesterase”, European Journal of Medicinal Chemistry, 2007, In press

7

C. T. Sadashiva, J. N. Narendra Sharath Chandra, K. C. Ponnappa, T. Veerabasappa Gowda and Kanchugarakoppal S. Rangappa. “Synthesis and Efficacy of 1-[bis(4- fluorophenyl)-methyl]piperazine Derivatives for Acetylcholinesterase Inhibition, as a Stimulant of Central Cholinergic Neurotransmission in Alzheimer’s Disease” Bioorganic & Medicinal Chemistry Letters. 16, 2006, 3932–3936.

8

J. N. Narendra Sharath Chandra, C. T. Sadashiva, C. V. Kavitha and K. S. Rangappa. “Synthesis and In-vitro Antimicrobial Studies of Medicinally Important Novel N- alkyl and N-sulfonyl Derivatives of 1-[bis(4-fluorophenyl)- methyl]piperazine”, Bioorganic & Medicinal Chemistry. 14, 2006, 6621-6627

9

C. T. Sadashiva, S. Naveen, J. N. Narendra Sharath Chandra, M. A. Sridhar, K. S. Rangappa and J. Shashidhara Prasad. “Crystal Structure Analysis of a Bioactive Piperazine Analog 1-[bis-(4-fluorophenyl)-Methyl]-4-methane sulfonyl piperazine”, Molecular crystals and Liquid Crystals. 469, 2006, 89-97

10

K. S. Rangappa, J. N. Narendra Sharath Chandra, C. T. Sadashiva and S. B. Benaka Prasad. “Designing Arecoline Analogues as M1 Receptor Stimulant to Treat Alzheimer’ Dementia”, my SCIENCE. 1(1), 2006, 19-42